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Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M – 2013

During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics. Pitstop 2™ is the first small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis. We investigated its effects on a second function for clathrin in mitosis.

Titel
Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
Verfasser
Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M
Datum
2013
Kennung
10.1186/1476-4598-12-4
Zitierweise
Molecular Cancer 2013, 12:4
Art
Text
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