Metal-free, regioselective triazole ligations deliver locked cis-peptide mimetics
Ahsanullah, P. Schmieder, R. Kühne, J. Rademann – 2009
Metal-free triazole turns: 1,5-Disubstituted peptidyl triazoles are obtained regioselectively from the 1,3-dipolar cycloaddition of peptidyl phosphoranes and azides. Peptide turns are thus formed that contain a conformationally locked cis peptide bond. Being regioselective and free of heavy metals, this reaction may find broad application in chemical biology and medicinal chemistry.