Biodegradable Polyglycerol Sulfates Exhibit Promising Features for Anti-inflammatory Applications
M. Ferraro, K. Silberreis, E. Mohammadifar, F. Neumann, J. Dernedde, R. Haag – 2018
Inflammatory processes are beneficial responses to overcome injury or illness. Knowledge of the underlying mechanisms allows for a specific treatment. Thus, synthetic systems can be generated for a targeted interaction. In this context, dendritic polyglycerol sulfates (dPGS) have been investigated as anti-inflammatory compounds. Biodegradable systems are required to prevent compound accumulation in the body. Here we present biodegradable analogs of dPGS based on hyperbranched poly(glycidol-co-caprolactone) bearing a hydrophilic sulfate outer shell (hPG-co-PCLS). The copolymers were investigated regarding their physical and chemical properties. The cytocompatibility was confirmed using A549, Caco-2, and HaCaT cells. Internalization of hPG-co-PCLS by A549 and Caco-2 cells was observed as well. Moreover, we demonstrated that hPG-co-PCLS acted as a competitive inhibitor of the leukocytic cell adhesion receptor L-selectin. Further, a reduction of complement activity was observed. These new biodegradable dPGS analogs are therefore attractive for therapeutic applications regarding inflammatory diseases.