Switchable electrostatic interactions between gold nanoparticles and coiled coil peptides direct colloid assembly.
S.C. Wagner, M. Roskamp, C. Böttcher, S. Schlecht, B. Koksch – 2009
The nanoparticle–peptide interaction described here is based on electrostatic forces and the pH value can act as a trigger to direct the organization of functionalized nanoparticles in a reversible and repeatable manner. The ability of the peptide to interact with the charged gold nanoparticles is directly related to its helical structure and was not found for a random coil peptide with the same net charge. Interestingly, the interaction with nanoparticles seems to induce a fibrillation of the coiled coil peptide.