Synthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β–Sheet Aggregation
J. J. Klein, S. Hecht – 2012
The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.