Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

P. Kiran, S. Kumari, J. Dernedde, S. Bhatia, R. Haag – 2019

Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN.

Titel
Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
Verfasser
P. Kiran, S. Kumari, J. Dernedde, S. Bhatia, R. Haag
Datum
2019
Kennung
10.1039/C9NJ02018G
Zitierweise
New J. Chem., 2019,43, 16012-16016
Art
Text
dfg_logo