Chemoselective triazole-phosphonamidate conjugates suitable for photo-release

K.D. Siebertz, C.P.R. Hackenberger – 2018

Herein, we describe a new method for the conjugation of azide-containing target compounds that can be readily released as amines by irradiation with near UV light. This concept is based on a two-step protocol employing the chemoselective CuAAC and Staudinger-phosphonite reactions to deliver photo-cleavable phosphonamidate conjugates in high yields starting from 2-nitrobenzyl substituted phosphonites.

Titel
Chemoselective triazole-phosphonamidate conjugates suitable for photo-release
Verfasser
K.D. Siebertz, C.P.R. Hackenberger
Datum
2018
Kennung
10.1039/C7CC08605A
Zitierweise
Chem. Commun., 2018, 54, 763-766
Art
Text
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