Glycan-Specific Metabolic Oligosaccharide Engineering of C7-Substituted Sialic Acids

H. Möller, V. Böhrsch, J. Bentrop, J. Bender, S. Hinderlich, C. P. R. Hackenberger – 2012

A new sialic acid in the house! A biosynthetic approach gives access to previously inaccessible C7 modifications of sialic acids in living cells. Metabolic incorporation of synthetically derived N-acetyl-4-azido-4-deoxymannosamine (see scheme) into glycans of mammalian cells and zebrafish larvae preserves the bioorthogonal functionality of its azido group for subsequent labeling with biophysical probes.

Titel
Glycan-Specific Metabolic Oligosaccharide Engineering of C7-Substituted Sialic Acids
Verfasser
H. Möller, V. Böhrsch, J. Bentrop, J. Bender, S. Hinderlich, C. P. R. Hackenberger
Datum
2012
Kennung
10.1002/anie.201108809
Zitierweise
Angew. Chem. Int. Ed. 2012, 51, 5986 - 5990
Art
Text
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