The Alzheimer’s disease-related tau protein as a new target for chemical protein engineering

M. Broncel, E. Krause, D. Schwarzer, C. P. R. Hackenberger – 2012

Site-specifically phosphorylated tau: A semisynthetic strategy has been applied for the first time to generate a phosphorylated and biotinylated fully functional tau protein (see figure). The presented methodology allows for an unambiguous verification of individual phosphorylation sites on tau and significantly improves its purification.

Titel
The Alzheimer’s disease-related tau protein as a new target for chemical protein engineering
Verfasser
M. Broncel, E. Krause, D. Schwarzer, C. P. R. Hackenberger
Datum
2012
Kennung
10.1002/chem.201103032
Zitierweise
Chem. Eur. J. 2012, 18, 2488 - 2492
Art
Text
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