Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

L.M. Artner, L. Merkel, N. Bohlke, F. Beceren-Braun, C. Weise, J. Dernedde, N. Budisa, C.P.R. Hackenberger – 2012

A combination of classical site-directed mutagenesis, genetic code engineering and bioorthogonal reactions delivered a chemically modified barstar protein with one or four carbohydrates installed at specific residues. These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands.

Titel
Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds
Verfasser
L.M. Artner, L. Merkel, N. Bohlke, F. Beceren-Braun, C. Weise, J. Dernedde, N. Budisa, C.P.R. Hackenberger
Datum
2012
Kennung
10.1039/C1CC16039G
Zitierweise
Chem. Commun. 2012, 48, 522 - 524
Art
Text
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