Site-specific Functionalisation of Proteins by a Staudinger-type reaction using unsymmetrical phosphites

V. Böhrsch, R. Serwa, P. Majkut, E. Krause, C.P.R. Hackenberger – 2010

Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phosphoramidates.

Titel
Site-specific Functionalisation of Proteins by a Staudinger-type reaction using unsymmetrical phosphites
Verfasser
V. Böhrsch, R. Serwa, P. Majkut, E. Krause, C.P.R. Hackenberger
Datum
2010
Kennung
10.1039/b926818a
Zitierweise
Chem. Commun. 2010, 46, 3176-3178
Art
Text
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