Cyclative cleavage of azido-peptidyl-phosphoranes delivers locked cis-triazolyl-cyclopeptides as privileged protein binders

Ahsanullah, J. Rademann – 2010

Support and guidance: Azidopeptidyl phosphoranes on a solid support react very efficiently through cyclative cleavage to yield cyclopeptides with an incorporated triazole ring. The solid support is advantageous as cyclization is favored strongly over oligomerization reactions and thus only cyclized products are released.

Titel
Cyclative cleavage of azido-peptidyl-phosphoranes delivers locked cis-triazolyl-cyclopeptides as privileged protein binders
Verfasser
Ahsanullah, J. Rademann
Datum
2010
Kennung
10.1002/anie.200904980
Zitierweise
Angew. Chem. Int. Ed. 2010, 49, 5378 –5382
Art
Text
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