Metal-free, regioselective triazole ligations deliver locked cis-peptide mimetics

Ahsanullah, P. Schmieder, R. Kühne, J. Rademann – 2009

Metal-free triazole turns: 1,5-Disubstituted peptidyl triazoles are obtained regioselectively from the 1,3-dipolar cycloaddition of peptidyl phosphoranes and azides. Peptide turns are thus formed that contain a conformationally locked cis peptide bond. Being regioselective and free of heavy metals, this reaction may find broad application in chemical biology and medicinal chemistry.

Titel
Metal-free, regioselective triazole ligations deliver locked cis-peptide mimetics
Verfasser
Ahsanullah, P. Schmieder, R. Kühne, J. Rademann
Datum
2009
Kennung
10.1002/anie.200806390
Zitierweise
Angew. Chem. Int. Ed. 2009, 48, 5042-5045
Art
Text
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