Amino sugars and their mimetics via 1,2-oxazines

F. Pfrengle, H.-U. Reissig – 2010

This tutorial review covers recent research from our laboratory towards the synthesis of amino sugars and related carbohydrate mimetics employing 1,2-oxazines as crucial intermediates. The synthesis of new dideoxyamino carbohydrate derivatives, C2-branched 4-amino sugars and their mimetics, as well as sialic acid analogues, has been developed during the last few years. The results demonstrate that alkoxyallenes are ideal and versatile components for the chain elongation of carbohydrate derivatives. Our routes starting from 3,6-dihydro-2H-1,2-oxazines are presented in conjunction with two related examples from the recent literature. Finally, we discuss possible future applications of the described compounds as anti-inflammatory agents.

Titel
Amino sugars and their mimetics via 1,2-oxazines
Verfasser
F. Pfrengle, H.-U. Reissig
Datum
2010
Kennung
10.1039/b914356d
Zitierweise
Chem.Soc.Rev. 2010, 39, 549-557
Art
Text
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