DNA as Molecular Ruler: Interrogation of a Tandem SH2 Domain with Self-Assembled, Bivalent DNA–Peptide Complexes

H. Eberhard, F. Diezmann, O. Seitz – 2011

Two peptides on display: The self-assembly of DNA complexes enables the bivalent presentation of phosphopeptides. Flexibility and distance in the ligand arrangement can be adjusted through the choice of appropriate DNA templates. Spatial screening of the tandem SH2 domain of Syk kinase with these probes indicated the accessible arrangements of the two homologous binding pockets and the flexibility of the connecting protein linker.

Titel
DNA as Molecular Ruler: Interrogation of a Tandem SH2 Domain with Self-Assembled, Bivalent DNA–Peptide Complexes
Verfasser
H. Eberhard, F. Diezmann, O. Seitz
Datum
2011
Kennung
10.1002/anie.201007593
Zitierweise
Angew. Chem. Int. Ed. 2011, 50, 1-6.
Art
Text
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