DNA-Triggered Synthesis and Bioactivity of Proapoptotic Peptides

A. Erben, T.N. Grossmann, O. Seitz – 2011

A great leap for an amino acid is enabled by a DNA-triggered reaction which involves the transfer of an aminoacyl group from a donating thioester-linked PNA–peptide hybrid to a peptide–PNA acceptor (see scheme). The formed peptide conjugates acted as antagonists to the X-linked inhibitor of apoptosis protein (XIAP) and allowed reactivation of initiator caspase-9 as well as the executioner

Titel
DNA-Triggered Synthesis and Bioactivity of Proapoptotic Peptides
Verfasser
A. Erben, T.N. Grossmann, O. Seitz
Datum
2011
Kennung
10.1002/anie.201007103
Zitierweise
Angew. Chem. Int. Ed. 2011, 50, 2828 - 2832
Art
Text
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