Benzoylphosphonate-based photoactive phosphopeptide mimetics for functional modulation of protein tyrosine phosphatases and highly specific covalent labeling of SH2-domains

A. Horatscheck, S. Wagner, J. Ortwein, M. Lisurek, B. G. Kim, S. Beligny, A. Schütz, J. Rademann – 2012

A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to “turn off” the activity of target proteins and to label them covalently (see scheme). Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research.

Titel
Benzoylphosphonate-based photoactive phosphopeptide mimetics for functional modulation of protein tyrosine phosphatases and highly specific covalent labeling of SH2-domains
Verfasser
A. Horatscheck, S. Wagner, J. Ortwein, M. Lisurek, B. G. Kim, S. Beligny, A. Schütz, J. Rademann
Datum
2012
Kennung
DOI: 10.1002/anie.201201475
Quelle/n
Zitierweise
Angew. Chem. Int. Ed. 2012, 51, 9441-9447
Art
Text
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