Shell Cleavable Dendritic Polyglycerol Sulfates Show High Anti-Inflammatory Properties by Inhibiting L-Selectin Binding and Complement Activation

Sabine Reimann, Dominic Gröger, Christian Kühne, Sebastian B. Riese, Jens Dernedde, and Rainer Haag – 2015

A new class of fully synthetic shell cleavable multivalent polysulfates is prepared by introducing degradable linkers into a stable biocompatible dendritic polyglycerol scaffold and subsequent sulfation. The sulfated polymers show different degradation profiles, low anticoagulant and high anti-inflammatory properties, are able to efficiently bind to L-selectin and inhibit the complement activation at very low concentrations in vitro.

Titel
Shell Cleavable Dendritic Polyglycerol Sulfates Show High Anti-Inflammatory Properties by Inhibiting L-Selectin Binding and Complement Activation
Verfasser
Sabine Reimann, Dominic Gröger, Christian Kühne, Sebastian B. Riese, Jens Dernedde, and Rainer Haag
Datum
2015
Kennung
10.1002/adhm.201500503
Zitierweise
Adv. Healthc. Mater., 2015, 4, 2154–2162
Art
Text
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