Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.

S. Malhotra, M. Calderon, A. K. Prasad, V. S. Parmar, R. Haag – 2010

In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO2) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.

Titel
Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.
Verfasser
S. Malhotra, M. Calderon, A. K. Prasad, V. S. Parmar, R. Haag
Datum
2010
Kennung
10.1039/B927021C
Quelle/n
Zitierweise
Org. Biomol. Chem., 2010, 8, 2228-2237.
Art
Text
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