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Molecular co-assembly to generate ultra-short bioactive peptide hydrogel wound dressing material

C. K. Thota, A. A. Berger, L. Elomaa, C. Nie, C. Böttcher, B. Koksch – 2020

Multicomponent self-assembly of peptides is a powerful strategy to fabricate novel functional materials with synergetic properties that can be used for several nanobiotechnological applications. In the present study, we used a coassembly strategy to generate an injectable ultrashort bioactive peptide hydrogel formed by mixing a dipeptide hydrogelator with a macrophage attracting short chemotactic peptide ligand. Coassembly does not impede hydrogelation as shown by cryo-transmission electron microscopy (cryo-TEM), scanning electron microscopy, and rheology. Biocompatibility was shown by cytotoxicity assays and confocal microscopy. The hydrogels release the entrapped skin antibiotic ciprofloxacin, among others, in a slow and continuous manner. Such bioinspired advanced functional materials can find applications as wound dressing materials to treat chronic wound conditions like diabetic foot ulcer.

Titel
Molecular co-assembly to generate ultra-short bioactive peptide hydrogel wound dressing material
Verfasser
C. K. Thota, A. A. Berger, L. Elomaa, C. Nie, C. Böttcher, B. Koksch
Datum
2020
Kennung
10.1021/acsomega.9b04371
Zitierweise
ACS Omega 2020, 5, 15, 8557–8563
Art
Text
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