Inhibition of selectin binding by colloidal gold with functionalized shells.

J. Dernedde, S. Enders, H.-U. Reissig, M. Roskamp, S. Schlecht, S. Yekta – 2009

Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC50 values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.

Titel
Inhibition of selectin binding by colloidal gold with functionalized shells.
Verfasser
J. Dernedde, S. Enders, H.-U. Reissig, M. Roskamp, S. Schlecht, S. Yekta
Datum
2009
Kennung
10.1039/b818263a
Quelle/n
Zitierweise
Chem. Comm. 2009, 8, 932-934
Art
Text
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