Synthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β–Sheet Aggregation

J. J. Klein, S. Hecht – 2012

The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.

Titel
Synthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β–Sheet Aggregation
Verfasser
J. J. Klein, S. Hecht
Datum
2012
Kennung
10.1021/ol203074p
Zitierweise
Org. Lett., 2012, 14(1), 330–333
Art
Text
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