Elucidating the backbone conformation of photoswitchable foldamers using vibrational circular dichroism

S. R. Domingos, S. J. Roeters, S. Amirjalayer, Z. Yu, S. Hecht, S. Woutersen – 2013

The backbone conformation of amphiphilic oligo(azobenzene) foldamers is investigated using vibrational circular dichroism (VCD) spectroscopy on a mode involving the stretching of the N[double bond, length as m-dash]N bonds in the backbone. From denaturation experiments, we find that the VCD response in the helical conformation arises mainly from through-space interaction between the N[double bond, length as m-dash]N-stretch transition-dipole moments, so that the coupled-oscillator model can be used to predict the VCD spectrum associated with a particular conformation. Using this approach, we elucidate the origin of the VCD signals in the folded conformation, and can assign the observed partial loss of VCD signals upon photo-induced unfolding to specific conformational changes. Our results show that the N[double bond, length as m-dash]N-stretch VCD response provides an excellent probe of the helical conformation of the N[double bond, length as m-dash]N bonds in this type of switchable molecular system.

Titel
Elucidating the backbone conformation of photoswitchable foldamers using vibrational circular dichroism
Verfasser
S. R. Domingos, S. J. Roeters, S. Amirjalayer, Z. Yu, S. Hecht, S. Woutersen
Datum
2013
Kennung
DOI: 10.1039/C3CP53243G
Quelle/n
Zitierweise
Phys. Chem. Chem. Phys. 2013, 15, 17263-17267
Art
Text
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