A Practical Two-Step Procedure for the Preparation of Enantiopure Pyridines: Multicomponent Reactions of Alkoxyallenes, Nitriles and Carboxylic Acids followed by a Cyclocondensation Reaction.

C. Eidamshaus, R. Kumar, M.K. Bera, H.-U. Reissig – 2011

A practical approach to highly functionalized 4-hydroxypyridine derivatives with stereogenic side chains in the 2- and 6-positions is described. The presented two-step process utilizes a multicomponent reaction of alkoxyallenes, nitriles and carboxylic acids to provide β-methoxy-β-ketoenamides which are transformed into 4-hydroxypyridines in a subsequent cyclocondensation. The process shows broad substrate scope and leads to differentially substituted enantiopure pyridines in good to moderate yields. The preparation of diverse substituted lactic acid derived pyrid-4-yl nonaflates is described. Additional evidence for the postulated mechanism of the multicomponent reaction is presented.

Titel
A Practical Two-Step Procedure for the Preparation of Enantiopure Pyridines: Multicomponent Reactions of Alkoxyallenes, Nitriles and Carboxylic Acids followed by a Cyclocondensation Reaction.
Verfasser
C. Eidamshaus, R. Kumar, M.K. Bera, H.-U. Reissig
Datum
2011
Kennung
10.3762/bjoc.7.108
Quelle/n
Zitierweise
Beilstein J. Org. Chem. 2011, 7, 962-975.
Art
Text
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