Three-Component Synthesis of Highly Functionalized 5-Acetyloxazoles.

T. Lechel, D. Lentz, H.-U. Reissig – 2009

By a flexible three-component synthesis, alkoxy-substituted enamides are easily available from lithiated alkoxyallenes, nitriles and carboxylic acids (see scheme). The treatment of these versatile intermediates with trifluoroacetic acid provided 5-acetyloxazoles in moderate to good yields. Different substituents are possible at C-2 and C-5 and the 5-acetyl group is a suitable handle for further synthetic transformations.

Titel
Three-Component Synthesis of Highly Functionalized 5-Acetyloxazoles.
Verfasser
T. Lechel, D. Lentz, H.-U. Reissig
Datum
2009
Kennung
10.1002/chem.200900386
Quelle/n
Zitierweise
Chemistry-A European Journal 2009, 15, 5432-5435.
Art
Text
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