Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes

Karol Nowosinski, Larissa K. S. von Krbek, Nora L. Traulsen, and Christoph A. Schalley – 2015

A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and positive chelate cooperativity thus providing profound insight into the effects governing multivalent binding in these pseudorotaxanes.

Titel
Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes
Verfasser
Karol Nowosinski, Larissa K. S. von Krbek, Nora L. Traulsen, and Christoph A. Schalley
Datum
2015
Kennung
10.1021/acs.orglett.5b02592
Zitierweise
Org. Lett., 2015, 17 (20), 5076–5079
Art
Text
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