Enzyme-responsive polymer-substituted pillararene amphiphiles: synthesis, self-assembly in water, and application in controlled drug release
Lingyan Gao, Bo Zheng, Wei Chen and Christoph A. Schalley – 2015
An enzyme-responsive drug delivery system was constructed from a pillararene-based polyethyleneglycol-substituted amphiphile which self-assembles into micelles in water. These micelles exhibit superior drug encapsulation capability, and display drug release behaviour in response to enzyme catalysis, in particular to L-asparaginase. Doxorubicin-loaded micelles show significant cytotoxicity against MCF-7 cancer cells.