Enzyme-responsive polymer-substituted pillar[5]arene amphiphiles: synthesis, self-assembly in water, and application in controlled drug release

Lingyan Gao, Bo Zheng, Wei Chen and Christoph A. Schalley – 2015

An enzyme-responsive drug delivery system was constructed from a pillar[5]arene-based polyethyleneglycol-substituted amphiphile which self-assembles into micelles in water. These micelles exhibit superior drug encapsulation capability, and display drug release behaviour in response to enzyme catalysis, in particular to L-asparaginase. Doxorubicin-loaded micelles show significant cytotoxicity against MCF-7 cancer cells.

Titel
Enzyme-responsive polymer-substituted pillar[5]arene amphiphiles: synthesis, self-assembly in water, and application in controlled drug release
Verfasser
Lingyan Gao, Bo Zheng, Wei Chen and Christoph A. Schalley
Datum
2015
Kennung
10.1039/C5CC06207A
Zitierweise
Chem. Commun., 2015, 51, 14901-14904
Art
Text
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